Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SELL | P14151 | 1/20 | 0.36 |
| ▸ | SELP | P16109 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 5/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11974268 | 0.75 | LMNA (0.48) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL27782409 | 0.73 | ALOX15 (0.36) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL10707456 | 0.71 | ESR1 (0.42) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL10641890 | 0.71 | ADRA1D (0.49) | LMNAADRA1AKMT2AKDM4EALDH1A1 | |
| SCHEMBL10640146 | 0.71 | ESR1 (0.45) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL7942520 | 0.70 | GABRA1 (0.61) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL26125757 | 0.69 | KMT2A (0.46) | ADRA1AKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL1913594 | 0.67 | ALDH1A1 (0.57) | KMT2AKDM4EALDH1A1POLBMAPT | |
| SCHEMBL18357201 | 0.67 | ACHE (0.59) | LMNATRPA1CHRM1SLC6A2ADRA1A | |
| SCHEMBL12974481 | 0.67 | LMNA (0.35) | LMNATRPA1CHRM1SLC6A2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0173634-B1 | 4-(ARYLPIPERAZINYLETHYLAMINOETHOXY) PHENOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTICAL APPLICATION | CORTIAL S.A. (FR) | 1988-08-31 | — | — | EP | claimed |