Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | GABRP | O00591 | 3/20 | 0.57 |
| ▸ | GABRD | O14764 | 3/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.57 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.57 |
| ▸ | GABRE | P78334 | 3/20 | 0.57 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.57 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.57 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642534 | 0.90 | GABRP (0.58) | KDM4EALDH1A1MAPTSMN1; SMN2GABRP | |
| Hydrochloric Acid SCHEMBL10641678 | 0.89 | GABRP (0.57) | KDM4EALDH1A1MAPTSMN1; SMN2GABRP | |
| SCHEMBL27763175 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MAPTSMN1; SMN2GABRPGABRD | |
| SCHEMBL2492034 | 0.81 | CYP3A4 (0.51) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10644994 | 0.78 | PBRM1 (0.46) | KDM4EALDH1A1SMN1; SMN2GABRPGABRD | |
| SCHEMBL7382514 | 0.78 | GABRA1 (0.62) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7384128 | 0.77 | GABRA1 (0.67) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL10642551 | 0.77 | PARP1 (0.49) | KDM4EHSD17B10ALDH1A1SMN1; SMN2GABRP | |
| SCHEMBL7382652 | 0.76 | GABRA1 (0.58) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7382610 | 0.76 | GABRA1 (0.66) | KDM4EHSD17B10ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731358-A | β-carbolines and their use as tranquilizers | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-03-15 | — | — | US | disclosed |