Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.45 |
| ▸ | GABRP | O00591 | 3/20 | 0.45 |
| ▸ | GABRD | O14764 | 3/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.45 |
| ▸ | GABRE | P78334 | 3/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642551 | 0.86 | PARP1 (0.49) | PBRM1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL10642534 | 0.80 | GABRP (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6007642 | 0.80 | IMPDH2 (0.55) | PBRM1GABRA1GABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL10641678 | 0.79 | GABRP (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10644635 | 0.78 | KDM4E (0.58) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2492034 | 0.77 | CYP3A4 (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10643286 | 0.76 | CHUK (0.50) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27763175 | 0.76 | ALDH1A1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL30634927 | 0.75 | IMPDH2 (0.61) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL5830751 | 0.75 | IMPDH2 (0.61) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731358-A | β-carbolines and their use as tranquilizers | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-03-15 | — | — | US | disclosed |