Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.60 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | MGMT | P16455 | 4/20 | 0.46 |
| ▸ | PNP | P00491 | 1/20 | 0.46 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 8/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 7/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL2128709 | 0.83 | PNP (0.70) | GDAATAD2PNP | |
| Adenine SCHEMBL8860590 | 0.83 | PI4KA (0.59) | PDPK1GDAATAD2PNPCDK2 | |
| Guanine SCHEMBL6515057 | 0.83 | PNP (0.70) | GDAATAD2PNP | |
| Adenine SCHEMBL906215 | 0.83 | PI4KA (0.59) | PDPK1GDAATAD2PNPCDK2 | |
| Guanine SCHEMBL29171220 | 0.83 | PNP (0.70) | GDAATAD2PNP | |
| Guanine SCHEMBL1375444 | 0.83 | PNP (0.70) | GDAATAD2PNP | |
| Adenine SCHEMBL4633068 | 0.83 | PI4KA (0.59) | PDPK1GDAATAD2PNPCDK2 | |
| Hypoxanthine SCHEMBL3348064 | 0.80 | ATAD2 (0.63) | PDPK1GDAATAD2PNP | |
| Guanine SCHEMBL6130674 | 0.80 | PNP (0.58) | GDAATAD2PNP | |
| Guanine SCHEMBL4348108 | 0.80 | PNP (0.58) | GDAATAD2PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8057997-B2 | Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20110021365-A1 | Nucleic Acid Binding Compounds Containing Pyrazolo[3,4-D]Pyrimidine Analogues of Purin-2,6-Diamine and Their Uses | ROCHE MOLECULAR SYSTEMS, INC. | 2011-01-27 | — | — | US | disclosed |
| EP-1307469-B1 | NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO¬3,4-D PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES | ROCHE DIAGNOSTICS GMBH (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-7238795-B2 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2007-07-03 | — | — | US | disclosed |
| US-20030198982-A1 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses | ROCHE MOLECULAR SYSTEMS, INC. | 2003-10-23 | — | — | US | disclosed |
| EP-1307469-A1 | NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO[3,4-D]PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES | BOEHRINGER MANNHEIM GMBH (DE) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012263-A1 | NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO[3,4-D]PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES | ROCHE DIAGNOSTICS GMBH (DE) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030198982-A1 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses | ADAR, NT5C3B, NT5C2 | PDPK1 3082/4885GDA 78/4885ATAD2 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.