Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656232 | 0.73 | ALOX5 (0.40) | KDM4EMAPTTDP1GAASQOR | |
| SCHEMBL10653878 | 0.69 | ADORA1 (0.43) | KDM4EMAPTTDP1GAAALDH1A1 | |
| SCHEMBL9260410 | 0.67 | RXRA (0.66) | KDM4EMAPTTDP1GAATHRB | |
| SCHEMBL29426410 | 0.67 | RXRA (0.66) | KDM4EMAPTTDP1GAATHRB | |
| SCHEMBL5089020 | 0.67 | FNTA (0.49) | RXRARXRBBRD4BRD2CREBBP | |
| SCHEMBL1982690 | 0.67 | PRKCZ (0.65) | KDM4EMAPTSQORALDH1A1HPGD | |
| SCHEMBL29012837 | 0.66 | RXRA (0.64) | KDM4EMAPTTDP1GAATHRB | |
| SCHEMBL5698013 | 0.65 | RXRA (0.55) | KDM4EMAPTTDP1GAATHRB | |
| SCHEMBL10655060 | 0.65 | GRIA4 (0.47) | KDM4EMAPTSQORALDH1A1HPGD | |
| SCHEMBL10653113 | 0.64 | ALDH1A1 (0.41) | KDM4EMAPTTDP1SQORALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273602-A1 | 3-Cyano-4-arylthiophenes | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |