Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.44 |
| ▸ | DRD1 | P21728 | 5/20 | 0.44 |
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | DRD5 | P21918 | 5/20 | 0.44 |
| ▸ | DRD3 | P35462 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652180 | 0.93 | HTR1A (0.48) | DRD2HTR1ADRD4DRD3 | |
| SCHEMBL10652767 | 0.92 | DRD2 (0.48) | MAOBDRD2DRD4DRD3MAOA | |
| SCHEMBL10647591 | 0.91 | DRD4 (0.47) | DRD2HTR1ADRD1DRD4DRD5 | |
| SCHEMBL10648427 | 0.90 | MAOB (0.44) | MAOB | |
| SCHEMBL10413001 | 0.88 | MAOB (0.52) | MAOBDRD2HTR1ADRD4DRD3 | |
| SCHEMBL9582089 | 0.87 | KDM4E (0.48) | DRD2HTR1ADRD1DRD4DRD5 | |
| SCHEMBL10648649 | 0.86 | DRD2 (0.43) | MAOBDRD2HTR1ADRD1DRD4 | |
| SCHEMBL10647445 | 0.85 | HTR1A (0.52) | HTR1A | |
| SCHEMBL9582681 | 0.84 | HTR7 (0.53) | — | |
| SCHEMBL10646354 | 0.84 | DRD4 (0.47) | DRD2HTR1ADRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |