Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658060 | 0.90 | ALDH1A1 (0.42) | TSHRLMNAGPBAR1ALDH1A1KDM4E | |
| SCHEMBL10662256 | 0.87 | ALDH1A1 (0.44) | TSHRGPBAR1ALDH1A1KDM4EHPGD | |
| SCHEMBL4035353 | 0.85 | FFAR4 (0.44) | GPBAR1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL10657284 | 0.85 | FFAR4 (0.40) | TSHRGPBAR1HPGDNPC1RAB9A | |
| SCHEMBL10661727 | 0.84 | CASP1 (0.44) | GPBAR1ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL10663342 | 0.84 | PKM (0.43) | TSHRLMNAGPBAR1KDM4EHPGD | |
| SCHEMBL10659227 | 0.82 | TP53 (0.39) | TSHRGPBAR1HPGDSMN1; SMN2FFAR4 | |
| SCHEMBL10736238 | 0.80 | SLC6A9 (0.39) | GPBAR1FFAR4PPARGPPARDPPARA | |
| SCHEMBL10656221 | 0.79 | PPARA (0.40) | TSHRLMNAGPBAR1ALDH1A1HPGD | |
| SCHEMBL10661817 | 0.79 | FFAR4 (0.41) | GPBAR1NPC1FFAR4PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |