Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | FHIT | P49789 | 6/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.37 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10663342 | 0.91 | PKM (0.43) | TP53POLBRXFP1FFAR4ALOX15 | |
| SCHEMBL10659946 | 0.88 | FHIT (0.48) | POLBRXFP1FHITALOX15SMN1; SMN2 | |
| SCHEMBL10657284 | 0.88 | FFAR4 (0.40) | TP53POLBRXFP1FFAR4TSHR | |
| SCHEMBL4035353 | 0.88 | FFAR4 (0.44) | FFAR4GPBAR1HPGDPTGS1 | |
| SCHEMBL10735991 | 0.87 | FFAR4 (0.34) | TP53POLBRXFP1FFAR4SMPD1 | |
| SCHEMBL10660670 | 0.87 | TP53 (0.36) | TP53POLBRXFP1FFAR4ALOX15 | |
| SCHEMBL10661727 | 0.87 | CASP1 (0.44) | FFAR4SMPD1GPBAR1PTGS1 | |
| SCHEMBL10658060 | 0.84 | ALDH1A1 (0.42) | FFAR4TSHRSMN1; SMN2MAPTGPBAR1 | |
| SCHEMBL10662256 | 0.83 | ALDH1A1 (0.44) | POLBFFAR4TSHRSMN1; SMN2MEN1 | |
| SCHEMBL10662964 | 0.82 | TSHR (0.43) | FFAR4TSHRSMN1; SMN2MAPTGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | claimed |
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |