Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11204321 | 0.77 | MAOA (0.42) | MMP12MMP13KDM4EUSP2CSNK2A2 | |
| SCHEMBL21650697 | 0.73 | ALDH1A1 (0.41) | KDM4EUSP2NPC1RAB9AKMT2A | |
| SCHEMBL28089760 | 0.71 | MAOA (0.39) | KDM4EVKORC1NPC1RAB9AKMT2A | |
| SCHEMBL10943956 | 0.70 | MAOA (0.54) | KDM4EUSP2CSNK2A2PTGS1CSNK2B | |
| Xanthone SCHEMBL29093500 | 0.70 | MAOA (0.62) | KDM4EUSP2CSNK2A2PTGS1CSNK2B | |
| SCHEMBL11485002 | 0.70 | MMP12 (0.52) | MMP12MMP13KDM4EPTGS1NPC1 | |
| Hydrochloric Acid SCHEMBL11637777 | 0.69 | CYP2C19 (0.50) | USP2PTGS1TTRKMT2AMEN1 | |
| SCHEMBL11640926 | 0.69 | CYP2C19 (0.50) | USP2PTGS1TTRKMT2AMEN1 | |
| SCHEMBL28761758 | 0.69 | VKORC1 (0.69) | KDM4EVKORC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3701250 | 0.68 | PTGS2 (0.52) | KDM4EPTGS1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009343-A1 | MODULATORS OF AMYLOID AGGREGATION | PRAECIS PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | US | disclosed |
| US-7658917-B2 | Modulators of amyloid aggregation | PRAECIS PHARMACEUTICALS, INC. (US) | 2010-02-09 | — | — | US | disclosed |
| US-20040005307-A1 | Modulators of amyloid aggregation | PRAECIS PHARMACEUTICALS, INC. | 2004-01-08 | — | — | US | disclosed |
| US-20020098173-A1 | Modulators of amyloid aggregation | PRAECIS PHARMACEUTICALS, INC. | 2002-07-25 | — | — | US | disclosed |
| EP-0815134-B1 | MODULATORS OF AMYLOID AGGREGATION | PRAECIS PHARM INC (US) | 2002-06-05 | — | — | EP | disclosed |
| US-6319498-B1 | AMYLOIDOGENIC PROTEIN, OR FRAGMENT THEREOF, MODIFIED WITH CIS-DECALIN GROUP, CHOLANOYL STRUCTURE, CHOLYL GROUP, DIETHYLENETRIAMINEPENTAACETYL GROUP, MENTHOXYACETYL GROUP, FLUORESCEIN-CONTAINING GROUP, OR N-ACETYLNEURAMINYL GROUP | PRAECIS PHARMACEUTICALS INCORPORATED | 2001-11-20 | — | — | US | disclosed |
| US-5854204-A | Aβ peptides that modulate β-amyloid aggregation | PRAECIS PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0815134-A1 | MODULATORS OF AMYLOID AGGREGATION | Praecis Pharmaceuticals Incorporated (US) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028471-A1 | MODULATORS OF AMYLOID AGGREGATION | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 1996-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009343-A1 | MODULATORS OF AMYLOID AGGREGATION | APP, IAPP, APBA1 | MMP12 3040/4885MMP13 4395/4885KDM4E 4182/4885 |
| US-20040005307-A1 | Modulators of amyloid aggregation | APP, IAPP, APBA1 | MMP12 3427/4885MMP13 4412/4885KDM4E 4176/4885 |
| US-20020098173-A1 | Modulators of amyloid aggregation | APP, IAPP, APBA1 | MMP12 3427/4885MMP13 4412/4885KDM4E 4176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.