Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10681969 | 0.90 | MAPT (0.47) | CDC7LMNAMAPTGAAHTT | |
| SCHEMBL10678457 | 0.87 | LMNA (0.40) | CDC7LMNACYP1A2CYP3A4MAOA | |
| SCHEMBL10682462 | 0.87 | MAPT (0.53) | LMNAMAPTGAAHTTKMT2A | |
| SCHEMBL10681929 | 0.86 | CDC7 (0.42) | CDC7LMNACYP1A2CYP3A4MAOA | |
| SCHEMBL10684520 | 0.86 | UCHL1 (0.46) | LMNACYP1A2CYP3A4MAOAPDE3B | |
| SCHEMBL10683120 | 0.86 | PDE3B (0.53) | CDC7LMNACYP1A2CYP3A4PDE3B | |
| SCHEMBL10680367 | 0.84 | GAA (0.43) | LMNACYP3A4MAPTGAAHTT | |
| SCHEMBL7383615 | 0.83 | PDE3B (0.46) | LMNACYP3A4PDE3BPDE3AMAPT | |
| SCHEMBL10674925 | 0.82 | ALDH1A1 (0.53) | LMNACYP1A2CYP3A4MAOAPDE3B | |
| SCHEMBL10680981 | 0.81 | DRD2 (0.38) | CDC7CYP3A4PDE3BPDE3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |