Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859542 | 1.00 | MAPT (0.50) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1859934 | 0.99 | ALDH1A1 (0.50) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1859938 | 0.99 | ALDH1A1 (0.50) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17707255 | 0.99 | ALDH1A1 (0.50) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6131679 | 0.97 | MAPT (0.48) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 | |
| SCHEMBL4367409 | 0.87 | ALDH1A1 (0.62) | ALDH1A1GAALMNAMMP2SMN1; SMN2 | |
| SCHEMBL3317059 | 0.87 | ALDH1A1 (0.62) | ALDH1A1GAALMNAMMP2SMN1; SMN2 | |
| SCHEMBL240405 | 0.87 | ALDH1A1 (0.62) | ALDH1A1GAALMNAMMP2SMN1; SMN2 | |
| SCHEMBL11651148 | 0.86 | MMP2 (0.49) | MAPTALDH1A1LMNAMMP2DPP4 | |
| SCHEMBL28998132 | 0.86 | ALDH1A1 (0.47) | MAPTCRHBPCRHR2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081503-B1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA SPA (IT) | 2025-07-30 | — | — | EP | disclosed |
| US-12077484-B2 | Process for the synthesis of melphalan | INDENA S.P.A. (IT) | 2024-09-03 | — | — | US | disclosed |
| CN-114845991-B | Method for synthesizing melphalan | 意迪那有限公司 | 2024-05-07 | — | — | CN | disclosed |
| EP-3015488-B1 | PRODUCTION METHOD FOR POLYAMINO ACID | TAKEDA PHARMACEUTICALS CO (JP) | 2024-03-06 | — | — | EP | disclosed |
| US-11787761-B2 | Process for the synthesis of Melphalan | INDENA S.P.A. (IT) | 2023-10-17 | — | — | US | disclosed |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2023-09-14 | — | — | US | disclosed |
| US-20230094970-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2023-03-30 | — | — | US | disclosed |
| EP-4081503-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | Indena S.p.A. (IT) | 2022-11-02 | — | — | EP | disclosed |
| CN-114845991-A | Method for synthesizing melphalan | 因德纳有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-114315618-A | Preparation method of synthetic melphalan | 浙江恒腾福生物科技集团有限公司 | 2022-04-12 | — | — | CN | disclosed |
| EP-1117657-A1 | PHENYLALANINE DERIVATIVES AS ALPHA 4 INTEGRIN INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2001-07-25 | — | — | EP | disclosed |
| EP-1073434-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-2000043413-A2 | PYROGLUTAMIC ACID DERIVATIVES AND RELATED COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000018759-A1 | PHENYLALANINE DERIVATIVES AS ALPHA 4 INTEGRIN INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-06 | — | — | WO | disclosed |
| WO-1999055330-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |
| EP-0879227-A1 | TYROSIN-DERIVATE AS ALPHA-V-INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 1998-11-25 | — | — | EP | disclosed |
| US-5677322-A | THERAPY FOR AGING, DIABETES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| WO-1997023451-A1 | TYROSIN-DERIVATE AS ALPHA-V-INTEGRIN INHIBITORS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-07-03 | — | — | WO | disclosed |
| EP-0638075-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994019335-A1 | THIAZOLE OR IMIDAZOLE DERIVATIVES AS MAILLARD REACTION INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230094970-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | PAH, IL4I1, TYR | MAPT 4067/4885CRHBP 3358/4885CRHR2 3283/4885 |
| US-12077484-B2 | Process for the synthesis of melphalan | PAH, TYR, IL4I1 | MAPT 3868/4885CRHBP 3254/4885CRHR2 2991/4885 |
| US-11787761-B2 | Process for the synthesis of Melphalan | PAH, TYR, MARS1 | MAPT 3926/4885CRHBP 3285/4885CRHR2 2890/4885 |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | PAH, TYR, IL4I1 | MAPT 3868/4885CRHBP 3254/4885CRHR2 2991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.