Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690462 | 0.84 | AMY1A (0.40) | CYP1A2PDE5APDE3BPDE3A | |
| SCHEMBL10688260 | 0.82 | NR1I2 (0.34) | CYP1A2 | |
| SCHEMBL10691918 | 0.82 | PKM (0.38) | PKMP2RX3P2RX2PTGES2CA12 | |
| SCHEMBL10686151 | 0.81 | EGFR (0.35) | CYP1A2 | |
| SCHEMBL10681085 | 0.78 | METAP2 (0.41) | PKMP2RX3P2RX2CA12CA2 | |
| SCHEMBL10690574 | 0.75 | PDE2A (0.51) | CYP1A2PDE5APDE3BPDE3A | |
| SCHEMBL10690513 | 0.74 | AMY1A (0.47) | CYP1A2PDE5APDE3BPDE3A | |
| SCHEMBL10689035 | 0.74 | ESR1 (0.42) | PDE5APDE3BPDE3A | |
| SCHEMBL10691998 | 0.72 | ADORA2B (0.42) | PKMCA12CA2CA9CA1 | |
| SCHEMBL10687750 | 0.71 | PKM (0.39) | PKMCA12CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |