Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690528 | 0.91 | SIGMAR1 (0.56) | LMNASTAT3ADRA1DADRA1AADRA1B | |
| SCHEMBL10686642 | 0.90 | SIGMAR1 (0.55) | LMNASTAT3ADRA1DADRA1AADRA1B | |
| SCHEMBL10685213 | 0.86 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BSIGMAR1ESR1 | |
| SCHEMBL10686306 | 0.83 | ADRA1D (0.53) | ADRA1DADRA1AADRA1BSIGMAR1ESR1 | |
| SCHEMBL10681421 | 0.83 | ADRA1D (0.48) | ADRA1DADRA1AADRA1BSIGMAR1ESR1 | |
| SCHEMBL10682913 | 0.81 | ACHE (0.54) | LMNAADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL10690877 | 0.81 | KDM4E (0.48) | LMNASTAT3ADRA1DADRA1AADRA1B | |
| SCHEMBL10687988 | 0.81 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BSIGMAR1ESR1 | |
| SCHEMBL10688707 | 0.81 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BSIGMAR1ESR1 | |
| SCHEMBL10682960 | 0.74 | DRD2 (0.48) | LMNAADRA1DADRA1AADRA1BESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4719208-A | 1,2,3,4,5,6-hexahydroazepino(4,5-B)indole derivatives, their preparation, intermediate compounds, and their application in therapeutics | OMNICHEM SOCIETE ANONYME (BE) | 1988-01-12 | — | — | US | disclosed |
| EP-0203902-A2 | 1,2,3,4,5,6-Hexahydro-azepino[4,5-b] indole derivatives, their preparation, intermediate compounds and their therapeutical use | OMNICHEM Société anonyme (BE) | 1986-12-03 | — | — | EP | disclosed |