Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692555 | 0.88 | CA2 (0.43) | KDM4EPDE2AMEN1KMT2APDE5A | |
| SCHEMBL10692548 | 0.86 | MAPT (0.46) | KDM4EPDE2AMEN1KMT2APDE5A | |
| SCHEMBL10687815 | 0.81 | EGFR (0.37) | KDM4EJAK2TYK2JAK3BRAF | |
| SCHEMBL10691571 | 0.81 | PDE2A (0.41) | KDM4EJAK2JAK1TYK2JAK3 | |
| SCHEMBL10971444 | 0.80 | PDE5A (0.47) | TAS2R14KDM4EJAK2JAK1TYK2 | |
| SCHEMBL10746559 | 0.80 | PDE2A (0.44) | KDM4EBRAFTNNI3KPDE2AMEN1 | |
| SCHEMBL10691729 | 0.79 | MEN1 (0.41) | TAS2R14KDM4EJAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL10746408 | 0.79 | PDE2A (0.43) | KDM4EBRAFTNNI3KPDE2AMEN1 | |
| SCHEMBL10747695 | 0.78 | PDE2A (0.65) | KDM4EPDE2AMEN1KMT2APDE5A | |
| SCHEMBL10690686 | 0.78 | EGLN2 (0.39) | KDM4EPDE2AMEN1KMT2APDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |