Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692555 | 0.87 | CA2 (0.43) | ALDH1A1EGFRKDRKDM4ELMNA | |
| SCHEMBL10690895 | 0.86 | TAS2R14 (0.40) | MAPTALDH1A1MAPK1EGFRKDR | |
| SCHEMBL10689169 | 0.85 | MAPT (0.48) | MAPTALDH1A1SMN1; SMN2NPSR1GAA | |
| SCHEMBL10691571 | 0.80 | PDE2A (0.41) | ALDH1A1GAAKDRKDM4ELMNA | |
| SCHEMBL10672480 | 0.79 | MAPT (0.49) | MAPTALDH1A1SMN1; SMN2NPSR1EGFR | |
| SCHEMBL10689653 | 0.78 | MAPT (0.45) | MAPTALDH1A1SMN1; SMN2NPSR1GAA | |
| Hydrochloric Acid SCHEMBL10748007 | 0.78 | MAPT (0.45) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL10690686 | 0.77 | EGLN2 (0.39) | ALDH1A1KDM4ELMNAPDE2APDE5A | |
| SCHEMBL10685898 | 0.77 | MAPT (0.46) | MAPTALDH1A1SMN1; SMN2NPSR1EGFR | |
| SCHEMBL10964780 | 0.77 | MAPT (0.46) | MAPTALDH1A1SMN1; SMN2NPSR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |