Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CDK4 | P11802 | 8/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.42 |
| ▸ | CCND1 | P24385 | 8/20 | 0.42 |
| ▸ | CDK2 | P24941 | 8/20 | 0.42 |
| ▸ | CCND3 | P30281 | 8/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688606 | 0.86 | PDE7A (0.48) | GAACDK2FGFR1DHODHHTT | |
| SCHEMBL10692684 | 0.86 | ADORA2B (0.46) | KMT2ADHODHMEN1LMNAHTT | |
| SCHEMBL10685364 | 0.84 | MKNK1 (0.46) | DHODHPARP1 | |
| SCHEMBL10688582 | 0.84 | PDE5A (0.38) | KMT2ADHODHMEN1LMNAHTT | |
| SCHEMBL10686161 | 0.83 | CDK4 (0.42) | KMT2ACDK4CCNA2CCND1CDK2 | |
| SCHEMBL10690944 | 0.83 | EGLN2 (0.39) | KMT2ADHODHMEN1LMNAHTT | |
| SCHEMBL10691435 | 0.82 | ROCK2 (0.46) | FGFR1DHODHLMNAMAPT | |
| SCHEMBL10869682 | 0.82 | KDM4E (0.43) | FGFR1KDRDHODHMAPTHTT | |
| SCHEMBL10613299 | 0.82 | MGAM (0.44) | GAAKMT2ACDK4CCNA2CCND1 | |
| SCHEMBL10686472 | 0.82 | PDE5A (0.37) | GAAKMT2ADHODHMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |