Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693845 | 0.82 | GAA (0.43) | FGFR1DHODHLMNAMAPT | |
| SCHEMBL10685364 | 0.81 | MKNK1 (0.46) | ROCK2ROCK1DHODH | |
| SCHEMBL10692684 | 0.80 | ADORA2B (0.46) | DHODHLMNA | |
| SCHEMBL10688606 | 0.80 | PDE7A (0.48) | IMPDH2IMPDH1PDE7AFGFR1FGFR2 | |
| SCHEMBL10688582 | 0.78 | PDE5A (0.38) | PDE7ADHODHNPC1RAB9ALMNA | |
| SCHEMBL10686161 | 0.78 | CDK4 (0.42) | IMPDH2DHODHLMNA | |
| SCHEMBL10690944 | 0.78 | EGLN2 (0.39) | ROCK2GSK3BDHODHPIM1CSNK2A2 | |
| SCHEMBL10691729 | 0.77 | MEN1 (0.41) | THRBDHODHLMNAMAPTL3MBTL1 | |
| SCHEMBL10869682 | 0.77 | KDM4E (0.43) | FGFR1DHODHNPC1RAB9AMAPT | |
| SCHEMBL10686472 | 0.77 | PDE5A (0.37) | PDE7ADHODHCSNK2A2CSNK2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |