Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171141 | 0.88 | HSD11B1 (0.50) | PSIP1MAPTHSD11B1L3MBTL1POLB | |
| Diethylamine SCHEMBL10690280 | 0.80 | PSIP1 (0.53) | PSIP1MAPTHSD11B1L3MBTL1POLB | |
| SCHEMBL9449199 | 0.78 | SNCA (0.49) | MAPTL3MBTL1POLBALDH1A1KDM4E | |
| SCHEMBL8509754 | 0.78 | ADAM17 (0.42) | MAPTPOLBALDH1A1KDM4EMMP1 | |
| SCHEMBL5567443 | 0.77 | CA1 (0.43) | MAPTALDH1A1KDM4E | |
| SCHEMBL10688783 | 0.76 | PSIP1 (0.57) | PSIP1MAPTHSD11B1L3MBTL1POLB | |
| Diethylamine SCHEMBL5874415 | 0.76 | SMN1; SMN2 (0.67) | PSIP1HSD11B1POLBALDH1A1KDM4E | |
| SCHEMBL15711923 | 0.76 | CA2 (0.47) | PSIP1MAPTL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10617469 | 0.75 | POLB (0.57) | MAPTHSD11B1L3MBTL1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL10688779 | 0.75 | PSIP1 (0.55) | PSIP1MAPTHSD11B1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4754024-A | Fibre-reactive azo dyes containing vinylsulfonyl or analogous groups | CIBA-GEIGY CORPORATION | 1988-06-28 | — | — | US | disclosed |