Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DBH | P09172 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10775826 | 0.96 | ALDH1A1 (0.38) | ALDH1A1CYP1A2CYP2C9GAAKMT2A | |
| SCHEMBL7098217 | 0.91 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP2C9GAAKMT2A | |
| SCHEMBL10694577 | 0.85 | SLC6A2 (0.33) | ALDH1A1GAAKMT2AKDM4EALOX15 | |
| SCHEMBL4694745 | 0.80 | MAPT (0.47) | ALDH1A1GAAKMT2AKDM4EALOX15 | |
| SCHEMBL25569815 | 0.79 | ALDH1A1 (0.40) | ALDH1A1CYP1A2CYP2C9GAAKMT2A | |
| SCHEMBL7765239 | 0.79 | ALDH1A1 (0.58) | ALDH1A1GAAKMT2AKDM4EMAPT | |
| SCHEMBL24124204 | 0.77 | ALDH1A1 (0.40) | ALDH1A1GAAKDM4EALOX15CASP1 | |
| SCHEMBL10693463 | 0.77 | ATM (0.42) | ALDH1A1KDM4EALOX15CASP1CASP7 | |
| SCHEMBL10693207 | 0.77 | GNG2 (0.45) | ALDH1A1MAPT | |
| SCHEMBL25569789 | 0.76 | MAPT (0.35) | ALDH1A1CYP1A2GAAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4791104-A | HYPOTENSIVE, ANTILIPEMIC, ANTIHROMBOTIC, ANTIHYPOXIC AGENTS | MAGGIONI-WINTHROP S.P.A. (IT) | 1988-12-13 | — | — | US | disclosed |
| WO-1987002359-A1 | DIHYDROBENZOTHIOPHENE AND THIOCHROMANE AMINOALCOHOLS | MAGGIONI-WINTHROP S.P.A. (IT) | 1987-04-23 | — | — | WO | disclosed |
| US-4638070-A | HYPOTENSIVE | CONTINENTAL PHARMA (BE) | 1987-01-20 | — | — | US | disclosed |