Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 5/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694109 | 0.89 | POLB (0.35) | HTR7LMNAMAPTALDH1A1DRD2 | |
| SCHEMBL10691444 | 0.86 | ALDH1A1 (0.43) | OPRL1HTR7ALDH1A1SCN9AHTR1A | |
| SCHEMBL10694576 | 0.84 | POLB (0.33) | HTR7LMNAMAPTALDH1A1DRD2 | |
| SCHEMBL10690584 | 0.81 | ALDH1A1 (0.36) | OPRL1MAPTOPRK1ALDH1A1HTR1A | |
| SCHEMBL10755079 | 0.80 | HTR1A (0.40) | OPRL1HTR7ALDH1A1HTR1ADRD2 | |
| SCHEMBL10694080 | 0.79 | NPC1 (0.45) | OPRL1HTR7SCN9AHTR1A | |
| SCHEMBL10696619 | 0.79 | RAD52 (0.34) | OPRL1MAPTOPRK1ALDH1A1HTR1A | |
| SCHEMBL10693548 | 0.78 | RAD52 (0.35) | OPRL1MAPTOPRK1ALDH1A1HTR1A | |
| Oxalic Acid SCHEMBL10688530 | 0.77 | SMPD1 (0.45) | MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL10688129 | 0.77 | ALDH1A1 (0.38) | OPRL1HTR7ALDH1A1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |