Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPI | P34949 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492692 | 0.94 | MPI (0.48) | MPITDP1MAPTKMT2AHCAR3 | |
| SCHEMBL2489209 | 0.77 | TDP1 (0.72) | MPITDP1MAPTKMT2AALDH1A1 | |
| SCHEMBL13341324 | 0.77 | MPI (0.40) | MPITDP1MAPTKMT2AMEN1 | |
| SCHEMBL23578343 | 0.76 | SIRT6 (0.44) | MPITDP1MAPTALDH1A1CYP2C19 | |
| SCHEMBL5563212 | 0.76 | RECQL (0.42) | MPITDP1MAPTKMT2ACYP2C19 | |
| SCHEMBL13341327 | 0.74 | MEN1 (0.37) | MPITDP1MAPTKMT2AMEN1 | |
| SCHEMBL10693972 | 0.72 | NPC1 (0.41) | MPITDP1MAPTKMT2AHCAR3 | |
| SCHEMBL2144620 | 0.72 | CASP1 (0.49) | MPITDP1MAPTKMT2AALDH1A1 | |
| SCHEMBL15543815 | 0.72 | CASP1 (0.53) | KMT2AALDH1A1MEN1POLBTP53 | |
| SCHEMBL10696897 | 0.71 | L3MBTL1 (0.51) | MAPTKMT2AALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |