Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | MC3R | P41968 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.33 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826624 | 0.77 | ADORA3 (0.37) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL13729259 | 0.76 | SORD (0.40) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL13728021 | 0.75 | KDM4E (0.39) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL8918530 | 0.74 | — | — | |
| SCHEMBL8918540 | 0.74 | — | — | |
| SCHEMBL6305112 | 0.73 | NNMT (0.39) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL29519619 | 0.73 | NR3C2 (0.35) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL1257943 | 0.73 | IMPDH2 (0.37) | — | |
| SCHEMBL532603 | 0.73 | XDH (0.34) | KDM4EKMT2AMEN1HPGD | |
| SCHEMBL163636 | 0.72 | ADORA3 (0.42) | ADORA3TSHRMC4RADRA1AMC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4794182-A | 2-Alkyl-4-amino-5-aminomethylpyrimidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-12-27 | — | — | US | disclosed |