Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696476 | 0.86 | BRD4 (0.47) | CDK2CCNA2CCNA1BRD4HTT | |
| SCHEMBL10695854 | 0.79 | CDK2 (0.49) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL10697819 | 0.75 | BRAF (0.41) | BRD4HTTSMN1; SMN2PDPK1ALDH1A1 | |
| SCHEMBL3969724 | 0.75 | BRD4 (0.45) | BRD4PDPK1ALDH1A1LMNA | |
| SCHEMBL11784078 | 0.73 | PDE5A (0.47) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL3960229 | 0.72 | HTT (0.41) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL22966379 | 0.72 | ALDH1A1 (0.47) | CDK2BRD4HTTMAP3K5PAK1 | |
| SCHEMBL9094494 | 0.71 | PDPK1 (0.64) | CDK2CCNA2CCNA1CDK1CCNB1 | |
| SCHEMBL2493987 | 0.69 | BRD4 (0.51) | CDK2BRD4PDPK1ALDH1A1LMNA | |
| SCHEMBL2988049 | 0.67 | NUDT1 (0.52) | CDK2CCNA2CCNA1BRD4CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254588-A1 | Imidazo[4,5-b] pyridine compounds, process for preparing same and pharmaceutical compositions containing same | TOKYO TANABE COMPANY LIMITED (JP) | 1988-01-27 | — | — | EP | claimed |