Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696440 | 0.92 | MEN1 (0.40) | MEN1KMT2AGAANPC1CYP19A1 | |
| SCHEMBL10697456 | 0.89 | MEN1 (0.40) | MEN1KMT2AGAANPC1CNR1 | |
| SCHEMBL10693698 | 0.85 | KDM4E (0.40) | SCN9ACYP19A1CNR2ALDH1A1HSD17B10 | |
| SCHEMBL10695289 | 0.84 | SCN9A (0.34) | MEN1KMT2AGAASCN9ACNR1 | |
| SCHEMBL10695087 | 0.82 | TNKS2 (0.44) | MEN1KMT2AGAASCN9AALDH1A1 | |
| SCHEMBL10696397 | 0.81 | ALDH1A1 (0.40) | MEN1KMT2AGAACYP19A1ALDH1A1 | |
| SCHEMBL10695201 | 0.81 | SCN9A (0.35) | MEN1KMT2AGAASCN9ACNR1 | |
| SCHEMBL10695114 | 0.81 | SCN9A (0.37) | MEN1KMT2AGAASCN9ACNR2 | |
| SCHEMBL10695491 | 0.79 | MAPT (0.42) | MEN1KMT2AGAASCN9ACNR2 | |
| SCHEMBL10695367 | 0.78 | KDM4E (0.42) | MEN1KMT2AGAASCN9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |