Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697356 | 0.92 | MEN1 (0.40) | MEN1KMT2ANPC1GAAALDH1A1 | |
| SCHEMBL10697456 | 0.92 | MEN1 (0.40) | MEN1KMT2ANPC1GAAALDH1A1 | |
| SCHEMBL10696042 | 0.84 | ALDH1A1 (0.39) | ALDH1A1HPGDHSD17B10PGRL3MBTL1 | |
| SCHEMBL10696318 | 0.78 | KDM4E (0.41) | MEN1KMT2AGAAALDH1A1HPGD | |
| SCHEMBL10695087 | 0.78 | TNKS2 (0.44) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL10698519 | 0.78 | CNR1 (0.41) | MEN1KMT2AGAAALDH1A1CASP1 | |
| SCHEMBL10698153 | 0.78 | AURKA (0.38) | PGRCYP19A1AURKAAURKB | |
| SCHEMBL10696397 | 0.77 | ALDH1A1 (0.40) | MEN1KMT2AGAAALDH1A1HPGD | |
| SCHEMBL10699769 | 0.77 | ALDH1A1 (0.41) | MEN1KMT2ANPC1GAAALDH1A1 | |
| SCHEMBL10693698 | 0.76 | KDM4E (0.40) | ALDH1A1HSD17B10CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |