Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | CASP7 | P55210 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695201 | 0.85 | SCN9A (0.35) | ADORA2BMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10698037 | 0.84 | ALDH1A1 (0.38) | SMN1; SMN2LMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL10698974 | 0.83 | KMT2A (0.37) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL10700273 | 0.83 | TNKS2 (0.43) | MAPK1LMNAMAPTMEN1KMT2A | |
| SCHEMBL10699950 | 0.81 | ADORA2B (0.33) | ADORA2BMAPK1SMN1; SMN2LMNAMAPT | |
| SCHEMBL10698284 | 0.79 | MEN1 (0.39) | MAPK1SMN1; SMN2LMNAMAPTMEN1 | |
| SCHEMBL10698470 | 0.79 | LMNA (0.32) | SMN1; SMN2LMNAMAPTRECQLTDP1 | |
| SCHEMBL10698195 | 0.78 | ADORA2B (0.35) | ADORA2BMAPK1PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL10700914 | 0.77 | HPGD (0.38) | SMN1; SMN2LMNAMAPTMEN1HTT | |
| SCHEMBL10698233 | 0.72 | AURKA (0.46) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |