Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10701079 | 0.87 | AURKA (0.39) | AURKAAURKB | |
| SCHEMBL10699950 | 0.83 | ADORA2B (0.33) | LMNASMN1; SMN2MAPTRECQLTDP1 | |
| SCHEMBL10698037 | 0.81 | ALDH1A1 (0.38) | LMNASMN1; SMN2MAPTRECQLAURKA | |
| SCHEMBL10700273 | 0.81 | TNKS2 (0.43) | LMNAMAPTTDP1 | |
| SCHEMBL10698974 | 0.81 | KMT2A (0.37) | LMNASMN1; SMN2MAPTRECQLTDP1 | |
| SCHEMBL10698241 | 0.79 | ADORA2B (0.34) | LMNASMN1; SMN2MAPTRECQLTDP1 | |
| SCHEMBL10696990 | 0.78 | — | — | |
| SCHEMBL10698284 | 0.77 | MEN1 (0.39) | LMNASMN1; SMN2MAPTRECQLTDP1 | |
| SCHEMBL10700914 | 0.75 | HPGD (0.38) | LMNASMN1; SMN2MAPTRECQL | |
| SCHEMBL10698460 | 0.73 | AURKA (0.48) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |