Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | IDE | P14735 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 5/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699435 | 0.88 | KMT2A (0.40) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10697413 | 0.86 | BMPR1B (0.39) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10698931 | 0.81 | KDM4E (0.41) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10700949 | 0.77 | BMPR1B (0.36) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10697745 | 0.75 | KMT2A (0.39) | KMT2AMEN1GAAARIDE | |
| SCHEMBL10699540 | 0.74 | TNKS2 (0.43) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10698178 | 0.73 | ALDH1A1 (0.40) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10700180 | 0.72 | BRD4 (0.36) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10698933 | 0.71 | KMT2A (0.36) | KMT2ABMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL10698699 | 0.69 | TOP1 (0.44) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |