Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10698957 | 0.88 | CYP1A2 (0.44) | KDM4EMEN1MAPK1KMT2AMAPT | |
| SCHEMBL10695340 | 0.83 | KDM4E (0.45) | KDM4EMEN1MAPK1KMT2AMAPT | |
| SCHEMBL10698710 | 0.81 | KMT2A (0.40) | MEN1KMT2ABMPR1BBMPR1ATGFBR1 | |
| SCHEMBL10700949 | 0.79 | BMPR1B (0.36) | KDM4EMEN1KMT2AMAPTRECQL | |
| SCHEMBL10697577 | 0.77 | KDM4E (0.40) | KDM4EMEN1MAPK1KMT2AMAPT | |
| SCHEMBL10701683 | 0.77 | KDM4E (0.40) | KDM4EMEN1MAPK1KMT2AMAPT | |
| SCHEMBL10698582 | 0.74 | CYP1A2 (0.41) | KDM4EMEN1MAPK1KMT2AMAPT | |
| SCHEMBL10698178 | 0.74 | ALDH1A1 (0.40) | KDM4EKMT2ABMPR1BBMPR1ATGFBR1 | |
| SCHEMBL10699549 | 0.73 | BMPR1B (0.41) | KDM4EMEN1MAPK1KMT2ARECQL | |
| SCHEMBL9832094 | 0.72 | CYP11B1 (0.53) | KDM4EMEN1MAPK1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |