Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699632 | 0.96 | MPI (0.38) | KMT2AKDM4EMPITDP1ALDH1A1 | |
| SCHEMBL2490105 | 0.78 | MPI (0.43) | KMT2AKDM4EMPITDP1ALDH1A1 | |
| SCHEMBL10693972 | 0.76 | NPC1 (0.41) | KMT2AMPITDP1ALDH1A1MAPT | |
| SCHEMBL23578343 | 0.68 | SIRT6 (0.44) | KDM4EMPITDP1ALDH1A1MAPT | |
| SCHEMBL10698788 | 0.67 | MAPT (0.55) | KMT2ATDP1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL15579146 | 0.67 | GAA (0.50) | KDM4ETDP1MAPTL3MBTL1POLB | |
| SCHEMBL10695006 | 0.67 | MPI (0.45) | KMT2AKDM4EMPITDP1ALDH1A1 | |
| SCHEMBL2489209 | 0.66 | TDP1 (0.72) | KMT2AKDM4EMPITDP1ALDH1A1 | |
| SCHEMBL17275758 | 0.66 | ALDH1A1 (0.47) | KMT2AKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL17275671 | 0.66 | ALDH1A1 (0.49) | KMT2AKDM4EALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |