Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172889 | 0.87 | HTR1A (0.57) | HTR1AHTR2BSIGMAR1DRD2DRD3 | |
| SCHEMBL24090506 | 0.85 | HTR2B (0.55) | HTR1AHTR2BSIGMAR1DRD2DRD3 | |
| SCHEMBL9627798 | 0.84 | HTR1A (0.50) | HTR1AHTR2BSIGMAR1DRD2DRD3 | |
| SCHEMBL9627910 | 0.80 | HTR1A (0.44) | HTR1AHTR2BSIGMAR1DRD2DRD3 | |
| SCHEMBL9628948 | 0.80 | HTR1A (0.55) | HTR1AHTR2BSIGMAR1DRD2DRD3 | |
| SCHEMBL9628688 | 0.79 | HTR2B (0.43) | HTR1AHTR2BSIGMAR1DRD2DRD3 | |
| SCHEMBL135119 | 0.78 | MTNR1A (0.65) | MTNR1A | |
| SCHEMBL136496 | 0.77 | MTNR1A (0.64) | MTNR1A | |
| SCHEMBL9628106 | 0.77 | PPARD (0.56) | — | |
| SCHEMBL3652699 | 0.77 | MTNR1A (0.54) | MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |