Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Itaconate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Itaconate SCHEMBL11692447 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL3209006 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL108568 | 0.97 | CA4 (0.56) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL9244087 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL2523981 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL18554541 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL7518248 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL7511457 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL106714 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 | |
| Itaconate SCHEMBL18554414 | 0.97 | CA4 (0.50) | CA4CASP1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 407 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119591805-A | Early-strength polycarboxylate superplasticizer with thickening and water-retaining properties and preparation method thereof | 中建西部建设新材料科技有限公司 | 2025-03-11 | — | — | CN | claimed |
| CN-119569957-A | Polycarboxylate superplasticizer and preparation method and application thereof | 科之杰新材料集团有限公司 | 2025-03-07 | — | — | CN | claimed |
| CN-119463055-A | Polycarboxylic acid slump retaining agent and preparation method and application thereof | 科之杰新材料集团有限公司 | 2025-02-18 | — | — | CN | claimed |
| US-20230149899-A1 | POROUS SUPERABSORBENT POLYMER MATERIAL FOR MICROALGAE HARVESTING | GEORGIA TECH RESEARCH CORPORATION | 2023-05-18 | — | — | US | claimed |
| US-20230093653-A1 | NUCLEATED POLYOLEFIN COMPOSITIONS AND METHODS AND USES THEREOF | BRASKEM S.A. (BR) | 2023-03-23 | — | — | US | claimed |
| US-11499039-B2 | Nucleated polyolefin compositions and methods and uses thereof | BRASKEM S.A. (BR) | 2022-11-15 | — | — | US | claimed |
| CN-111218036-A | Preparation process for improving folding resistance of leisure sole material | 界首市盛泽鞋业有限公司 | 2020-06-02 | — | — | CN | claimed |
| CN-111056817-A | Preparation method of environment-friendly coal gangue-based hollow brick | 和县明生环保材料有限责任公司 | 2020-04-24 | — | — | CN | claimed |
| US-20190225781-A1 | NUCLEATED POLYOLEFIN COMPOSITIONS AND METHODS AND USES THEREOF | BRASKEM S.A. (BR) | 2019-07-25 | — | — | US | claimed |
| EP-3481874-A1 | NUCLEATED POLYOLEFIN COMPOSITIONS AND METHODS AND USES THEREOF | Braskem S.A. (BR) | 2019-05-15 | — | — | EP | claimed |
| CN-107405288-A | The polymer of itaconic acid and its purposes in cosmetic product or personal care product as film forming agent | 伊塔康尼克（英国）有限公司 | 2017-11-28 | — | — | CN | claimed |
| US-20160250134-A1 | POLYMERS AND USES THEREOF | REVOLYMER (U.K.) LIMITED (GB) | 2016-09-01 | — | — | US | claimed |
| CN-105624819-A | Preparation method of hydrophilic polyacrylonitrile-based carbon fiber precursor | CHINA PETROLEUM & CHEM CORP | 2016-06-01 | — | — | CN | claimed |
| WO-2016075498-A1 | POLYMERS OF ITACONIC ACID AND USES THEREOF AS A FILM FORMING AGENT IN A COSMETIC OR PERSONAL CARE PRODUCT | REVOLYMER (U.K.) LIMITED (GB) | 2016-05-19 | — | — | WO | claimed |
| CN-103374854-B | A kind of papermaking filler special and the paper containing this filler | LI RUJI (CN) | 2015-11-04 | — | — | CN | claimed |
| CN-104815841-A | Heavy metal polluted soil in-situ chromatography governance method | BEIJING TAIKEMEI HI TECH CO LTD | 2015-08-05 | — | — | CN | claimed |
| CN-103374854-A | Specific papermaking filling and paper containing same | LI RUJI | 2013-10-30 | — | — | CN | claimed |
| US-4345006-A | Method of treating leather | ROHM GMBH (DE) | 1982-08-17 | — | — | US | claimed |
| US-4040970-A | WITH COPOLYMER FOR RENDERING THE TONER NEGATIVELY CHARGEABLE | CANON KABUSHIKI KAISHA (JA) | 1977-08-09 | — | — | US | claimed |
| US-3977983-A | Liquid developer for use in development of an electrostatic latent image comprising a copolymer containing an amino group converted into a quaternary ammonium salt or hydroxide | CANON KABUSHIKI KAISHA (JA) | 1976-08-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160250134-A1 | POLYMERS AND USES THEREOF | SUCLG1, CUTA, ETF1 | CA4 2913/4885CASP1 2876/4885CA12 3959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.