Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Itaconate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 known ✓ | P22748 | 6/20 | 0.56 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.32 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.32 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.32 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Itaconate SCHEMBL28469208 | 1.00 | CA4 (0.56) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Itaconate SCHEMBL108427 | 0.97 | CA4 (0.53) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Itaconate SCHEMBL107045 | 0.97 | CA4 (0.53) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Itaconate SCHEMBL7511457 | 0.94 | CA4 (0.50) | CA4FAHD1CASP1CA2CA1 | |
| Itaconate SCHEMBL3209006 | 0.94 | CA4 (0.50) | CA4FAHD1CASP1CA2CA1 | |
| Itaconate SCHEMBL7518248 | 0.94 | CA4 (0.50) | CA4FAHD1CASP1CA2CA1 | |
| Itaconate SCHEMBL18554541 | 0.94 | CA4 (0.50) | CA4FAHD1CASP1CA2CA1 | |
| Itaconate SCHEMBL9244087 | 0.94 | CA4 (0.50) | CA4FAHD1CASP1CA2CA1 | |
| Itaconate SCHEMBL2523981 | 0.94 | CA4 (0.50) | CA4FAHD1CASP1CA2CA1 | |
| Itaconate SCHEMBL106714 | 0.94 | CA4 (0.50) | CA4FAHD1CASP1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 813 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260117011-A1 | NOVEL BIO-BASED TERPOLYMER AND PREPARATION METHOD AND USE THEREOF | ALL PLUS CHEMICAL CO LTD (CN) | 2026-04-30 | — | — | US | claimed |
| EP-4653480-A1 | NEW BIO-BASED TERNARY POLYMER, AND PREPARATION METHOD THEREFOR AND USE THEREOF | All-Plus Chemical Co., Ltd. (CN) | 2025-11-26 | — | — | EP | claimed |
| US-20250207474-A1 | DRILLING AND CEMENTING UNIVERSAL FLUIDS AND METHODS AND SYSTEMS RELATED THERETO | SAUDI ARABIAN OIL COMPANY (SA) | 2025-06-26 | — | — | US | claimed |
| WO-2025136632-A1 | DRILLING AND CEMENTING UNIVERSAL FLUIDS AND METHODS AND SYSTEMS RELATED THERETO | SAUDI ARABIAN OIL COMPANY (SA) | 2025-06-26 | — | — | WO | claimed |
| CN-119736720-B | Polyacrylonitrile spinning solution and preparation method and application thereof | 清华大学 | 2025-06-10 | — | — | CN | claimed |
| CN-119770704-A | Developing embolism microsphere and preparation method thereof | 科睿驰（深圳）医疗科技发展有限公司 | 2025-04-08 | — | — | CN | claimed |
| CN-119736720-A | Polyacrylonitrile spinning solution and preparation method and application thereof | 清华大学 | 2025-04-01 | — | — | CN | claimed |
| CN-119733083-A | Temperature-sensitive embolism microsphere and preparation method and drug-loaded release application method thereof | 科睿驰（深圳）医疗科技发展有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119613357-A | Preparation method and application of bio-based itaconic acid diglycidyl ester | 中国科学院宁波材料技术与工程研究所 | 2025-03-14 | — | — | CN | claimed |
| CN-119569957-A | Polycarboxylate superplasticizer and preparation method and application thereof | 科之杰新材料集团有限公司 | 2025-03-07 | — | — | CN | claimed |
| US-6579417-B1 | Paper making process for manufacturing a fibrous sheet of paper or paperboard from an aqueous suspension or a fibrous mass of pulp by flocculating said pulp with at least one water soluble cross-linked polymeric retention agent | SNF S.A. (FR) | 2003-06-17 | — | — | US | claimed |
| US-20020137858-A1 | Polymer flocculants with improved dewatering characteristics | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) | 2002-09-26 | — | — | US | claimed |
| EP-1095665-A1 | WOUND-COVERING PREPARATION, WOUND-COVERING MATERIAL, AND METHOD OF WOUND HEALING | NOF CORPORATION (JP) | 2001-05-02 | — | — | EP | claimed |
| US-6209646-B1 | CAUSING LIQUID CHEMICAL ADDITIVE TO BE ABSORBED INTO POROUS SOLID MATERIAL WHEREBY LIQUID CHEMICAL IS ENCAPSULATED THEREBY AND COMBINING SAID ENCAPSULATED LIQUID CHEMICAL ADDITIVE WITH TREATING FLUID, INTRODUCING INTO WELL | HALLIBURTON ENERGY SERVICES, INC. | 2001-04-03 | — | — | US | claimed |
| WO-2000034581-A1 | POLYAMPHOLYTE COAGULANT IN THE PAPERMAKING PROCESS | CALGON CORPORATION a corporation of the State of Delaware (US) | 2000-06-15 | — | — | WO | claimed |
| EP-0296850-B1 | HYDROPHILIC GROUP-CONTAINING AB-TYPE BLOCK COPOLYMER | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1992-01-02 | — | — | EP | claimed |
| EP-0296850-A2 | Hydrophilic group-containing AB-type block copolymer | MITSUBISHI PETROCHEMICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | claimed |
| US-4040970-A | WITH COPOLYMER FOR RENDERING THE TONER NEGATIVELY CHARGEABLE | CANON KABUSHIKI KAISHA (JA) | 1977-08-09 | — | — | US | claimed |
| US-3977983-A | Liquid developer for use in development of an electrostatic latent image comprising a copolymer containing an amino group converted into a quaternary ammonium salt or hydroxide | CANON KABUSHIKI KAISHA (JA) | 1976-08-31 | — | — | US | claimed |
| US-3943223-A | Method of manufacturing acrylic fibers | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1976-03-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260117011-A1 | NOVEL BIO-BASED TERPOLYMER AND PREPARATION METHOD AND USE THEREOF | DAD1, DEPTOR, GLO1 | CA4 1005/4885CA2 1314/4885CA1 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.