Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10704260 | 0.79 | CES2 (0.33) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL1180396 | 0.78 | ALDH1A1 (0.45) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL9860353 | 0.78 | POLB (0.41) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL9860356 | 0.78 | POLB (0.41) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL29468147 | 0.76 | GPR27 (0.37) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL5871710 | 0.75 | KEAP1 (0.61) | KEAP1NFE2L2 | |
| SCHEMBL8508742 | 0.74 | POLB (0.43) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL221449 | 0.74 | KEAP1 (0.53) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL23272826 | 0.72 | CA12 (0.53) | POLBAPEX1HPGDMAPTTSHR | |
| SCHEMBL11045624 | 0.72 | PLAU (0.42) | POLBAPEX1HPGDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168732-B1 | PROCESS FOR THE PREPARATION OF HALOGENATED AROYLACETIC ACID ESTERS | BAYER AG (DE) | 1988-07-27 | — | — | EP | disclosed |
| US-4611080-A | Preparation of halogenated aroylacetic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1986-09-09 | — | — | US | disclosed |
| EP-0168732-A2 | Process for the preparation of halogenated aroylacetic acid esters | BAYER AG (DE) | 1986-01-22 | — | — | EP | disclosed |