Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10711888 | 0.83 | BRD4 (0.40) | CYP1A2CYP2C19HTR7GSK3BPTGS2 | |
| SCHEMBL10711127 | 0.82 | GSK3B (0.36) | PGRCYP3A4SMN1; SMN2GSK3BTDP1 | |
| SCHEMBL10712219 | 0.82 | GSK3B (0.38) | PGRCYP3A4SMN1; SMN2GSK3BTDP1 | |
| SCHEMBL10711932 | 0.80 | HDAC4 (0.40) | CYP3A4SMN1; SMN2TTRLRRK2PTGS2 | |
| SCHEMBL10715084 | 0.79 | PTGS2 (0.39) | PGRCYP3A4SMN1; SMN2GSK3BTDP1 | |
| SCHEMBL10711141 | 0.79 | CYP3A4 (0.38) | PGRCYP3A4SMN1; SMN2GSK3BTDP1 | |
| SCHEMBL10714343 | 0.77 | LMNA (0.41) | CYP3A4SMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10713691 | 0.77 | GSK3B (0.40) | PGRCYP3A4SMN1; SMN2GSK3BTDP1 | |
| SCHEMBL10711924 | 0.76 | PGR (0.38) | PGRCYP3A4SMN1; SMN2GSK3BTDP1 | |
| SCHEMBL10713389 | 0.74 | PGR (0.55) | PGRCYP3A4GSK3BTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |