Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.68 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30263065 | 1.00 | SIRT6 (0.68) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL11421909 | 0.89 | SIRT6 (0.52) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL27741418 | 0.85 | SIRT6 (0.68) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL30159768 | 0.83 | SIRT6 (0.72) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL287121 | 0.83 | SIRT6 (0.72) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL2059001 | 0.81 | SIRT6 (0.63) | SIRT6JUNNFKB1NFKB2RELA | |
| Hydrochloric Acid SCHEMBL9310461 | 0.81 | SIRT6 (0.69) | SIRT6JUNNFKB1NFKB2RELA | |
| Hydrochloric Acid SCHEMBL30263277 | 0.81 | SIRT6 (0.69) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL1432968 | 0.81 | SIRT6 (1.00) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL6078516 | 0.81 | SIRT6 (0.69) | SIRT6JUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 240 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728210-B1 | ISOXAZOLE N-LINKED CARBAMOYL CYCLOHEXYL ACIDS AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2026-02-11 | — | — | EP | disclosed |
| EP-4392419-B1 | NOVEL PYRAZINYL-TRIAZOLE COMPOUNDS AS PESTICIDES | BAYER AG (DE) | 2025-07-23 | — | — | EP | disclosed |
| US-12281116-B2 | HTT modulators for treating Huntington's disease | CHDI FOUNDATION, INC. (US) | 2025-04-22 | — | — | US | disclosed |
| CN-112041304-B | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists | 百时美施贵宝公司 | 2025-03-07 | — | — | CN | disclosed |
| WO-2025022915-A1 | METHOD FOR PRODUCING 2-ETHYLSULFONYL-1-HETEROARYLETHANONE COMPOUND | 日本曹達株式会社 | 2025-01-30 | — | — | WO | disclosed |
| CN-112041316-B | Isoxazole O-linked carbamoyl cyclohexyl acids as LPA antagonists | 百时美施贵宝公司 | 2024-11-22 | — | — | CN | disclosed |
| US-20240368125-A1 | NOVEL PYRAZINYL-TRIAZOLE COMPOUNDS AS PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2024-11-07 | — | — | US | disclosed |
| EP-4433471-A1 | N-(2H-INDAZOL-5-YL)PYRAZINE-2-CARBOXAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS HTT MODULATORS FOR THE TREATMENT OF HUNTINGTON'S DISEASE | CHDI Foundation, Inc. (US) | 2024-09-25 | — | — | EP | disclosed |
| CN-118510769-A | HTT modulators for the treatment of huntington's disease | CHDI基金会股份有限公司 | 2024-08-16 | — | — | CN | disclosed |
| EP-4392419-A1 | NOVEL PYRAZINYL-TRIAZOLE COMPOUNDS AS PESTICIDES | Bayer Aktiengesellschaft (DE) | 2024-07-03 | — | — | EP | disclosed |
| WO-2003050088-A1 | SUBSTITUTED HETEROCYCLIC CARBOXAMIDES WITH ANTITHROMBOTIC ACTIVITY | ELI LILLY AND COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |
| EP-1307444-A2 | SUBSTITUTED HETEROCYCLIC AMIDES | ELI LILLY AND COMPANY (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010154-A2 | SUBSTITUTED HETEROCYCLIC AMIDES | ELI LILLY AND COMPANY (US) | 2002-02-07 | — | — | WO | disclosed |
| US-5942387-A | Combinatorial process for preparing substituted thiophene libraries | ELI LILLY AND COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
| US-5811428-A | ADMINISTERING FOR THE TREATMENT AND PREVENTION OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0850228-A1 | PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-07-01 | — | — | EP | disclosed |
| EP-0825164-A2 | Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5643912-A | Pyrazinoic acid esters as anti-mycobacterium avium agents | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NY (US) | 1997-07-01 | — | — | US | disclosed |
| WO-1997009315-A1 | PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |
| US-5364939-A | Chlorinating hydroxy carboxylic acid with phosphorus pentachloride in phosphoroxy chloride | LONZA LTD. (CH) | 1994-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281116-B2 | HTT modulators for treating Huntington's disease | HTT, HYPK, ATXN2 | SIRT6 600/4885JUN 4044/4885NFKB1 3237/4885 |
| US-20240368125-A1 | NOVEL PYRAZINYL-TRIAZOLE COMPOUNDS AS PESTICIDES | PRDX1, PRDX5, PRXL2A | SIRT6 2123/4885JUN 4289/4885NFKB1 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.