Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716578 | 0.82 | PKM (0.49) | MAPTPKMP4HTMHDAC3HDAC1 | |
| SCHEMBL10726196 | 0.77 | PKM (0.52) | MAPTPKMCA2CA1CA4 | |
| SCHEMBL10730568 | 0.76 | PKM (0.51) | MAPTPKMCA2CA1CA4 | |
| SCHEMBL10726333 | 0.76 | PKM (0.48) | MAPTPKMP4HTMCA2CA1 | |
| SCHEMBL10716446 | 0.76 | MAPT (0.50) | MAPTPKMVNN1ALDH1A1LMNA | |
| SCHEMBL10726719 | 0.75 | PKM (0.52) | MAPTPKMCA2CA1CA4 | |
| SCHEMBL10717754 | 0.75 | ALDH1A1 (0.52) | MAPTPKMCA2CA1CA4 | |
| SCHEMBL10730881 | 0.74 | MAPT (0.54) | MAPTPKMALDH1A1LMNAPOLB | |
| SCHEMBL10730985 | 0.73 | MAPT (0.52) | MAPTPKMALDH1A1LMNAPOLB | |
| SCHEMBL10716583 | 0.73 | MAPT (0.56) | MAPTPKMCA2CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |