Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10718310 | 0.94 | CHRM3 (0.54) | CHRM3KMT2ACHRNB2CHRNB4CHRNA3 | |
| Fumaric Acid SCHEMBL10461342 | 0.81 | KMT2A (0.46) | CHRM3KMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8878800 | 0.78 | CHRM3 (0.59) | CHRM3KMT2ACHRM2CHRM1LMNA | |
| SCHEMBL9372375 | 0.74 | KMT2A (0.50) | CHRM3KMT2ACHRNB2CHRNB4CHRNA3 | |
| Maleic Acid SCHEMBL10360499 | 0.71 | HRH1 (0.44) | CHRM3KMT2ACHRM2CHRM1CHRM4 | |
| SCHEMBL4756753 | 0.70 | CHRM3 (0.50) | CHRM3KMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL4758054 | 0.70 | CHRM3 (0.49) | CHRM3KMT2ACHRM2CHRM1CHRM4 | |
| SCHEMBL5808342 | 0.69 | KEAP1 (0.43) | CHRM3KMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8424910 | 0.69 | KEAP1 (0.43) | CHRM3KMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL10461571 | 0.69 | CHRM3 (0.51) | CHRM3KMT2ACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235463-A2 | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-09-09 | — | — | EP | disclosed |