SCHEMBL10723745

SCHEMBL10723745

Nc1cccc2[nH]c(S(=O)(=O)Cc3ccccc3)nc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.47
MAPT P10636 3/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
POLB P06746 1/20 0.41
GAA P10253 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CHEK1 O14757 1/20 0.40
ALDH1A1 P00352 3/20 0.39
TP53 P04637 1/20 0.39
CYP2D6 P10635 1/20 0.38
HPGD P15428 2/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA5A P35218 1/20 0.38
CA9 Q16790 1/20 0.38
AKR1B1 P15121 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6841126 0.82 PARP1 (0.55)
SCHEMBL7209149 0.78 ALDH1A1 (0.59) XDHMAPTL3MBTL1GAAALDH1A1
SCHEMBL10723749 0.78 XDH (0.50) XDHMAPTL3MBTL1MEN1KMT2A
SCHEMBL10466652 0.77 L3MBTL1 (0.49) MAPTL3MBTL1MEN1KMT2APOLB
SCHEMBL2942698 0.76 L3MBTL1 (0.56) MAPTL3MBTL1MEN1KMT2APOLB
SCHEMBL8554234 0.74 MAPT (0.56) XDHMAPTL3MBTL1MEN1KMT2A
SCHEMBL8554228 0.74 XDH (0.46) XDHMAPTL3MBTL1MEN1KMT2A
SCHEMBL10466702 0.72 CHEK1 (0.45) MAPTL3MBTL1MEN1KMT2APOLB
SCHEMBL3790024 0.72 GAA (0.58) MAPTL3MBTL1MEN1KMT2APOLB
SCHEMBL9509578 0.70 L3MBTL1 (0.53) MAPTL3MBTL1MEN1KMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-62192366-A None JP disclosed
JP-S62192366-A SUBSTITUTED AMINOBENZYLSULFONYLBENZIMIDAZOLE COMPOUND NIPPON CHEMIPHAR CO LTD 1987-08-22 JP disclosed