Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | NCF1 | P14598 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | SORD | Q00796 | 2/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5916583 | 0.81 | METAP2 (0.54) | COMTNCF1ALDH1A1LMNAMAPT | |
| SCHEMBL11022181 | 0.81 | METAP2 (0.36) | HRH4NCF1CYP2A6NOS3NOS2 | |
| SCHEMBL10502118 | 0.79 | NPSR1 (0.44) | NCF1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL10747582 | 0.77 | METAP2 (0.40) | NCF1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL10502474 | 0.74 | ALDH1A1 (0.38) | NCF1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL10502218 | 0.74 | CYP1A2 (0.47) | HTR2CALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL10744770 | 0.73 | KDM4E (0.44) | NCF1CYP2A6SORDALDH1A1LMNA | |
| SCHEMBL10502470 | 0.72 | METAP2 (0.46) | NCF1ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL10501684 | 0.72 | SMN1; SMN2 (0.45) | ALDH1A1LMNAMAPTKDM4EGLA | |
| SCHEMBL10501411 | 0.72 | METAP2 (0.38) | NCF1ALDH1A1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |