Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.43 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.43 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020733 | 0.93 | METAP2 (0.38) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10748075 | 0.89 | MAPT (0.40) | METAP2MAPTNPC1RAB9AKMT2A | |
| SCHEMBL10501980 | 0.85 | METAP2 (0.41) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10745708 | 0.83 | TXNRD1 (0.56) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10503543 | 0.80 | METAP2 (0.50) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10501833 | 0.79 | NPC1 (0.43) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10502051 | 0.76 | SLC11A2 (0.40) | METAP2MAPTALDH1A1KDM4E | |
| SCHEMBL10747582 | 0.76 | METAP2 (0.40) | METAP2MAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL10746470 | 0.75 | METAP2 (0.52) | TXNRD1TXNRD3TXNRD2METAP2MAPT | |
| SCHEMBL10501793 | 0.75 | TXNRD1 (0.52) | TXNRD1TXNRD3TXNRD2METAP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711961-A | Benzisoselenazolethiones and process for the treatment of various diseases in humans | A. NATTERMANN & CIE GMBH (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0154851-A1 | Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds | A. Nattermann & Cie. GmbH (DE) | 1985-09-18 | — | — | EP | disclosed |