Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | CFB | P00751 | 7/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017363 | 0.92 | AR (0.50) | AMY1APKN1PKN2CFBCHEK2 | |
| SCHEMBL10762222 | 0.92 | AMY1A (0.41) | AMY1APKN1PKN2CFBCYP1A2 | |
| SCHEMBL11019300 | 0.88 | PKN1 (0.48) | AMY1APKN1PKN2CFBCHEK2 | |
| SCHEMBL11017329 | 0.83 | AR (0.50) | AMY1APKN1PKN2CFBCYP1A2 | |
| SCHEMBL11021674 | 0.81 | METAP2 (0.46) | PKN1PKN2CFBCHEK2METAP2 | |
| SCHEMBL11017902 | 0.80 | CHEK2 (0.53) | AMY1ACHEK2 | |
| SCHEMBL11018186 | 0.80 | CYP3A4 (0.48) | PKN1PKN2CFBCYP1A2CYP3A4 | |
| SCHEMBL11016463 | 0.79 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL11018211 | 0.79 | CHEK2 (0.47) | AMY1APKN1PKN2CFBCHEK2 | |
| SCHEMBL11018557 | 0.79 | PKN1 (0.44) | AMY1APKN1PKN2CFBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |