Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.63 |
| ▸ | HRH1 | P35367 | 2/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | HRH2 | P25021 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norpipanone SCHEMBL25085 | 0.83 | OPRM1 (0.75) | OPRM1KCNH2HRH1CYP2D6MAPK1 | |
| Norpipanone SCHEMBL316886 | 0.82 | OPRM1 (0.73) | OPRM1KCNH2HRH1CYP2D6MAPK1 | |
| Fenpipramide SCHEMBL149504 | 0.81 | CHRM2 (0.60) | OPRM1KCNH2HRH1CYP2D6MAPK1 | |
| SCHEMBL219257 | 0.81 | CHRM2 (0.60) | OPRM1KCNH2HRH1CYP2D6MAPK1 | |
| SCHEMBL1492481 | 0.81 | OPRM1 (0.63) | OPRM1KCNH2HRH1ADRA2ADRD4 | |
| Fenpipramide SCHEMBL11716116 | 0.81 | OPRM1 (0.56) | OPRM1KCNH2HRH1CYP2D6MAPK1 | |
| Fenpipramide SCHEMBL7558279 | 0.80 | CHRM2 (0.59) | OPRM1KCNH2HRH1CYP2D6MAPK1 | |
| SCHEMBL11722508 | 0.79 | CYP2D6 (0.57) | OPRM1KCNH2HRH1CYP2D6MAPK1 | |
| SCHEMBL12387673 | 0.78 | OPRM1 (1.00) | OPRM1KCNH2HRH1ADRA2AADRA2B | |
| SCHEMBL2313168 | 0.78 | OPRM1 (1.00) | OPRM1KCNH2HRH1ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0219898-A1 | Novel alpha,alpha-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-04-29 | — | — | EP | disclosed |