Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 9/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.31 |
| ▸ | PRKCG | P05129 | 2/20 | 0.31 |
| ▸ | PRKCB | P05771 | 2/20 | 0.31 |
| ▸ | PRKCA | P17252 | 2/20 | 0.31 |
| ▸ | PRKCH | P24723 | 2/20 | 0.31 |
| ▸ | PRKCI | P41743 | 2/20 | 0.31 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.31 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.31 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10709229 | 0.81 | CHRM2 (0.37) | CHRM2CHRM5CHRM1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL1415293 | 0.73 | CHRM2 (0.50) | CHRM2CHRM5CHRM1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL194196 | 0.72 | CHRM2 (0.45) | CHRM2CHRM5CHRM1TSHRMAPK1 | |
| SCHEMBL20162231 | 0.71 | CHRM2 (0.52) | CHRM2CHRM5CHRM1TSHRMAPK1 | |
| SCHEMBL5889866 | 0.70 | SMN1; SMN2 (0.34) | TSHRMAPK1 | |
| SCHEMBL587971 | 0.69 | — | — | |
| Iodide SCHEMBL11797425 | 0.69 | CHRM2 (0.54) | CHRM2CHRM5CHRM1TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL7942359 | 0.69 | PRKD3 (0.45) | CHRM2CHRM5CHRM1TSHRMAPK1 | |
| Ether SCHEMBL8028255 | 0.67 | CHRM2 (0.53) | CHRM2CHRM5CHRM1TSHRMAPK1 | |
| SCHEMBL19164287 | 0.67 | CHRM2 (0.48) | CHRM2CHRM5CHRM1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4703116-A | WET STRENGTH, DRY STRENGTH | NATIONAL STARCH AND CHEMICAL CORPORATION (US) | 1987-10-27 | — | — | US | disclosed |