Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10514546 | 0.69 | CA2 (0.47) | CA2LMNA | |
| SCHEMBL10514175 | 0.64 | CA2 (1.00) | CA2CA1CA9 | |
| SCHEMBL8024678 | 0.58 | CYP2C9 (0.83) | CA2CA1CA9LMNACYP2C9 | |
| SCHEMBL8024515 | 0.57 | CA2 (1.00) | CA2CA1CA9LMNACYP2C9 | |
| SCHEMBL8030116 | 0.55 | LMNA (0.56) | CA2CA1CA9LMNACYP2C9 | |
| SCHEMBL17114404 | 0.55 | CASP1 (0.46) | CA2CA1CA9LMNA | |
| SCHEMBL8323703 | 0.53 | CA2 (0.38) | CA2CA1CA9CA7 | |
| SCHEMBL2675124 | 0.53 | KMT2A (0.46) | CA2CA1CA9LMNACA7 | |
| SCHEMBL7873031 | 0.52 | CA2 (0.37) | CA2CA1CA9LMNACA7 | |
| SCHEMBL23416677 | 0.52 | HSD17B10 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4677115-A | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof | MERCK & CO., INC. (US) | 1987-06-30 | — | — | US | disclosed |
| EP-0189690-A1 | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them | MERCK & CO. INC. (US) | 1986-08-06 | — | — | EP | disclosed |