Sugi Predict

Sugi Predict / Compounds / SCHEMBL2675124

SCHEMBL2675124

SCHEMBL2675124

O=C1CCS(=O)(=O)c2ccccc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.46
▸ MDM2 Q00987 1/20 0.46
▸ CTDSP1 Q9GZU7 1/20 0.46
▸ GPR3 P46089 1/20 0.43
▸ CYP2A6 P11509 1/20 0.41
▸ MAOA P21397 1/20 0.41
▸ MAOB P27338 1/20 0.41
▸ TDP1 Q9NUW8 2/20 0.40
▸ CA2 P00918 4/20 0.39
▸ CA9 Q16790 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ CA12 O43570 1/20 0.39
▸ USP2 O75604 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ BCHE P06276 1/20 0.39
▸ CA4 P22748 1/20 0.39
▸ CA6 P23280 1/20 0.39
▸ CA5A P35218 1/20 0.39
▸ CA7 P43166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6205306 0.88 CYP2A6 (0.47) KMT2AMDM2CTDSP1GPR3CYP2A6
SCHEMBL181753 0.78 PLCG1 (0.47) KMT2AMDM2CTDSP1GPR3TDP1
SCHEMBL3491681 0.78 KMT2A (0.41) KMT2AMDM2CTDSP1GPR3CYP2A6
SCHEMBL10196638 0.78 KMT2A (0.46) KMT2AGPR3TDP1CA2CA9
SCHEMBL17114404 0.73 CASP1 (0.46) KMT2ATDP1CA2CA9KDM4E
SCHEMBL5199843 0.73 CA2 (0.33) CA2
SCHEMBL2675723 0.73 CTSL (0.51) TDP1CA2CA9CA12CA1
SCHEMBL1939074 0.73 POLB (0.46) KMT2ACA2CA1
SCHEMBL17193238 0.73 CTSL (0.39) KMT2AGPR3TDP1CA2CA9
SCHEMBL31396270 0.73 CTSL (0.42) TDP1CA2CA9CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583858-B2 TDO2 inhibitors GENENTECH, INC. (US) 2026-03-24 — — US disclosed
EP-3394068-B1 TDO2 INHIBITORS GENENTECH INC (US) 2024-09-11 — — EP disclosed
US-20220306635-A1 TDO2 Inhibitors GENENTECH, INC. 2022-09-29 — — US disclosed
CN-115010712-A TDO2 inhibitors 基因泰克公司 2022-09-06 — — CN disclosed
CN-110072864-B TDO2 inhibitors 基因泰克公司 2022-05-27 — — CN disclosed
EP-3489233-B1 INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) 2022-01-12 — — EP disclosed
US-10800780-B2 TDO2 Inhibitors GENENTECH, INC. (US) 2020-10-13 — — US disclosed
US-10800780-B2 TDO2 Inhibitors GENENTECH, INC. (US) 2020-10-13 — — US disclosed
US-10800765-B2 Indole derivative used as CRTH2 inhibitor CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2020-10-13 — — US disclosed
US-20190248770-A1 INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2019-08-15 — — US disclosed
EP-0749971-B1 Thiopyran derivatives SUNTORY LTD (JP) 2001-03-14 — — EP disclosed
US-6100265-A BENZOTHIOPYRAN AND THIENOTHIOPYRAN DERIVATIVES; SEROTONIN-2 BLOCKING ACTION; TREATMENT OF CIRCULATORY DISEASES IN GENERAL SUCH AS HYPERTENSION, ISCHEMIC HEART DISEASE, CEREBROVASCULAR DISTURBANCE, AND PERIPHERAL CIRCULATORY DISTURBANCE SUNTORY LIMITED (JP) 2000-08-08 — — US disclosed
US-5977111-A Thiopyran derivatives SUNTORY LIMITED (JP) 1999-11-02 — — US disclosed
EP-0749971-A1 Thiopyran derivatives SUNTORY LIMITED (JP) 1996-12-27 — — EP disclosed
EP-0411751-A1 Renin inhibitory peptides Beecham Group p.l.c. (GB) 1991-02-06 — — EP disclosed
US-4105778-A ANTIALLERGENS, BACTERICIDES, FUNGICIDES AYERST, MCKENNA & HARRISON, LTD. (CA) 1978-08-08 — — US disclosed
US-4060619-A ANTIALLERGY, MICROBIOCIDE AYERST MCKENNA AND HARRISON LTD. (CA) 1977-11-29 — — US disclosed
US-4046778-A Processes for the preparation of 4-hydroxy-2H-1-benzothiopyran-3-carboxamide 1,1-dioxides WARNER-LAMBERT COMPANY (US) 1977-09-06 — — US disclosed
US-4013686-A 4-(1-PYRROLIDINYL)-2H-1-BENZOTHIOPYRAN-1,1-DIOXIDE WARNER-LAMBERT COMPANY (US) 1977-03-22 — — US disclosed
US-4007203-A 4-(1-Pyrolidenyl)-2H-1-benzothiopyran-3-carboxanilide WARNER-LAMBERT COMPANY (US) 1977-02-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583858-B2 TDO2 inhibitors TDO2, IDO2, TPH2 KMT2A 2433/4885MDM2 3101/4885CTDSP1 1441/4885
US-20190248770-A1 INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR NR3C2, CRHR2, TPH2 KMT2A 2348/4885MDM2 2200/4885CTDSP1 3265/4885
US-10800765-B2 Indole derivative used as CRTH2 inhibitor NR3C2, CRHR2, TPH2 KMT2A 2348/4885MDM2 2200/4885CTDSP1 3265/4885
US-20220306635-A1 TDO2 Inhibitors TDO2, IDO2, IDO1 KMT2A 664/4885MDM2 429/4885CTDSP1 2536/4885
US-10800780-B2 TDO2 Inhibitors TDO2, IDO2, IDO1 KMT2A 785/4885MDM2 337/4885CTDSP1 2977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.