Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811918 | 0.90 | EGLN1 (0.39) | EGLN1ALKBH1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11018085 | 0.90 | RXRA (0.41) | EGLN1RAB9ASMN1; SMN2NPC1RXRA | |
| SCHEMBL10816686 | 0.90 | L3MBTL1 (0.43) | EGLN1ALKBH1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10813483 | 0.88 | EGLN1 (0.43) | EGLN1ALKBH1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10816545 | 0.87 | EGLN1 (0.41) | EGLN1ALKBH1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10814782 | 0.87 | EGLN1 (0.41) | EGLN1ALKBH1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL11021894 | 0.86 | ALKBH1 (0.41) | ALKBH1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL10815000 | 0.85 | RXRA (0.46) | EGLN1ALKBH1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL10813796 | 0.84 | RAB9A (0.46) | EGLN1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL11037277 | 0.80 | EGLN1 (0.44) | EGLN1RXRAGRIN1GRIN2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087326-B1 | SUBSTITUTED PYRIMIDIN-2-ONES AND THE SALTS THEREOF | NYCOMED AS (NO) | 1987-05-13 | — | — | EP | claimed |
| US-4539324-A | ANTICANCER AGENTS | NYEGAARD & CO. A/S (NO) | 1985-09-03 | — | — | US | claimed |
| EP-0087326-A1 | Substituted pyrimidin-2-ones and the salts thereof | NYCOMED AS (NO) | 1983-08-31 | — | — | EP | claimed |
| EP-0087326-B1 | SUBSTITUTED PYRIMIDIN-2-ONES AND THE SALTS THEREOF | NYCOMED AS (NO) | 1987-05-13 | — | — | EP | disclosed |
| US-4539324-A | ANTICANCER AGENTS | NYEGAARD & CO. A/S (NO) | 1985-09-03 | — | — | US | disclosed |
| EP-0087326-A1 | Substituted pyrimidin-2-ones and the salts thereof | NYCOMED AS (NO) | 1983-08-31 | — | — | EP | disclosed |