Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811050 | 0.90 | EGLN1 (0.43) | L3MBTL1NPC1RAB9ASMN1; SMN2EGLN1 | |
| SCHEMBL10811918 | 0.86 | EGLN1 (0.39) | L3MBTL1NPC1RAB9ASMN1; SMN2EGLN1 | |
| SCHEMBL11018085 | 0.86 | RXRA (0.41) | NPC1RAB9ASMN1; SMN2EGLN1TSHR | |
| SCHEMBL11037277 | 0.84 | EGLN1 (0.44) | EGLN1TSHRNPSR1ALDH1A1HPGD | |
| SCHEMBL10813483 | 0.84 | EGLN1 (0.43) | L3MBTL1NPC1RAB9ASMN1; SMN2EGLN1 | |
| SCHEMBL10811972 | 0.83 | ALDH1A1 (0.42) | L3MBTL1NPC1RAB9ASMN1; SMN2EGLN1 | |
| SCHEMBL11021894 | 0.82 | ALKBH1 (0.41) | NPC1RAB9ASMN1; SMN2TSHRALKBH1 | |
| SCHEMBL11170879 | 0.82 | HPGD (0.47) | L3MBTL1SMN1; SMN2EGLN1TSHRMAPK14 | |
| SCHEMBL10817552 | 0.81 | EGLN1 (0.47) | NPC1RAB9ASMN1; SMN2EGLN1NPSR1 | |
| SCHEMBL10818075 | 0.81 | RXRA (0.39) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087326-B1 | SUBSTITUTED PYRIMIDIN-2-ONES AND THE SALTS THEREOF | NYCOMED AS (NO) | 1987-05-13 | — | — | EP | disclosed |
| US-4539324-A | ANTICANCER AGENTS | NYEGAARD & CO. A/S (NO) | 1985-09-03 | — | — | US | disclosed |
| EP-0087326-A1 | Substituted pyrimidin-2-ones and the salts thereof | NYCOMED AS (NO) | 1983-08-31 | — | — | EP | disclosed |