Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | BLM | P54132 | 3/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.35 |
| ▸ | RECQL | P46063 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | THPO | P40225 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652141 | 0.70 | TDP1 (0.36) | TDP1LMNABLMNR1I2PTGS1 | |
| SCHEMBL11037767 | 0.70 | XDH (0.56) | PTGS1KDM4EMAPTPOLBKMT2A | |
| SCHEMBL28814337 | 0.70 | GABRA1 (0.39) | TDP1LMNAKDM4EMAPTTSHR | |
| SCHEMBL27984516 | 0.69 | ALOX5 (0.43) | LMNAPTGS1KDM4EHIF1AHSD17B10 | |
| SCHEMBL10958505 | 0.69 | ALDH1A1 (0.46) | TDP1KDM4ERECQLMAPTHSD17B10 | |
| SCHEMBL10649553 | 0.68 | TDP1 (0.35) | TDP1LMNABLMNR1I2PTGS1 | |
| SCHEMBL11079398 | 0.67 | ALDH1A1 (0.49) | TDP1LMNABLMKDM4ERECQL | |
| SCHEMBL3220830 | 0.64 | PNMT (0.35) | TDP1LMNATSHR | |
| SCHEMBL10585791 | 0.64 | ALDH1A1 (0.49) | LMNAKDM4EMAPTKMT2AHTT | |
| SCHEMBL13971484 | 0.62 | TDP1 (0.59) | TDP1LMNABLMNR1I2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4695589-A | HYPOTENSIVE AGENTS | STERLING DRUG INC. (US) | 1987-09-22 | — | — | US | disclosed |