SCHEMBL108320

SCHEMBL108320

Cc1ccc(C(=O)Cl)c(C)c1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.47
FLT1 P17948 1/20 0.46
FLT4 P35916 1/20 0.46
KDR P35968 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
HTT P42858 2/20 0.46
KMT2A Q03164 2/20 0.46
HSD11B1 P28845 1/20 0.45
TP53 P04637 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
ALDH1A1 P00352 2/20 0.43
MEN1 O00255 1/20 0.42
CSNK2A1 P68400 1/20 0.42
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
TAS1R3 Q7RTX0 2/20 0.41
TAS1R1 Q7RTX1 2/20 0.41
TAS1R2 Q8TE23 2/20 0.41
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL302204 0.84 CSNK2A1 (0.48) NFE2L2SMN1; SMN2HTTKMT2AMEN1
SCHEMBL4365448 0.82 RXRB (0.53) TDP1ALDH1A1
SCHEMBL1773780 0.82 CES2 (0.39) SMN1; SMN2HTTKMT2ATDP1ALDH1A1
SCHEMBL31634804 0.82 CES2 (0.39) SMN1; SMN2HTTKMT2ATDP1ALDH1A1
SCHEMBL1311663 0.82 MEN1 (0.53) SMN1; SMN2HTTKMT2AALDH1A1MEN1
SCHEMBL31369141 0.81 LMNA (0.50) NFE2L2FLT1FLT4KDRSMN1; SMN2
SCHEMBL286054 0.81 LMNA (0.50) NFE2L2FLT1FLT4KDRSMN1; SMN2
SCHEMBL9420260 0.81 NFE2L2 (0.55) NFE2L2FLT1FLT4KDRSMN1; SMN2
SCHEMBL670210 0.80 HPGD (0.51) SMN1; SMN2KMT2ATP53ALDH1A1MEN1
SCHEMBL107882 0.80 FLT1 (0.51) FLT1FLT4KDRSMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 234 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114957156-A Compound containing benzoxazine structure, resin composition, prepreg and electric copper clad laminate, and preparation method and application thereof 成都科宜高分子科技有限公司 2022-08-30 CN claimed
CN-104693062-B Phenylacetylene derivatives and preparation of the side base with ester group, polymerization and methods for using them 哈尔滨工程大学 2017-10-03 CN claimed
CN-104910039-A Functional phenylacetylene compound and preparation method thereof UNIV HARBIN ENG 2015-09-16 CN claimed
CN-104693062-A Phenylacetylene derivative with ester group on lateral base band and preparation, polymerization and application methods UNIV HARBIN ENG 2015-06-10 CN claimed
EP-2288652-B1 PREPARATION FOR INITIATING RADICAL REACTIONS UNITED INITIATORS GMBH & CO KG (DE) 2012-09-19 EP claimed
US-20110272628-A1 Preparation For Initiating Radical Reactions UNITED INITIATORS GMBH (DE) 2011-11-10 US claimed
EP-2130858-A1 Preparations to initiate radical reactions Degussa Initiators GmbH & Co. KG (DE) 2009-12-09 EP claimed
US-5210313-A Friedel crafts aryloylation of 1,4-dichlorobenzene and Lewis acids MAXDEM INCORPORATED (US) 1993-05-11 US claimed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 EP claimed
EP-4676923-A1 BIARYLAMIDE DERIVATIVES AND THEIR USE AS PKMYT1 INHIBITORS Cancer Research Technology Limited (GB) 2026-01-14 EP disclosed
CN-116178337-B Benzodiazepine compounds and their use as Rho kinase inhibitors 成都奥睿药业有限公司 2025-04-25 CN disclosed
CN-119176806-A Aceclidine prodrug, and preparation method and application thereof 上海英诺富成生物科技有限公司 2024-12-24 CN disclosed
WO-2024184550-A1 BIARYLAMIDE DERIVATIVES AND THEIR USE AS PKMYT1 INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-09-12 WO disclosed
CN-111875646-B Preparation method of 2' -oxygen-propynyluridine 上海兆维科技发展有限公司 2023-08-22 CN disclosed
US-4061851-A 7-Amino-7-arylthio cephalosporins E. R. SQUIBB & SONS, INC. (US) 1977-12-06 US disclosed
US-4029669-A 6-Benzalimino-6-arylthio penicillanic acids and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1977-06-14 US disclosed
US-4026886-A 7-Acyl-7-arylthiocephalosporins E. R. SQUIBB & SONS, INC. (US) 1977-05-31 US disclosed
US-4000275-A BENZIMIDAZO(2,1-B) QUINAZOLIN-12(6H)ONES ELI LILLY AND COMPANY (US) 1976-12-28 US disclosed
US-3965093-A 6-Arylthio penicillanic acid and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1976-06-22 US disclosed
US-3954744-A ANTIBACTERIAL E. R. SQUIBB & SONS, INC. (US) 1976-05-04 US disclosed